Though the structures are supported on soil, most of the designers do not consider the soil structure interaction and its subsequent effect on structure during an earthquake. Different soil properties can affect seismic waves as they pass through a soil layer. When a structure is subjected to an earthquake excitation, it interact the foundation and soil, and thus changes the motion of the ground. It means that the movement of the whole ground structure system is influenced by type of soil as well as by the type of structure. Tall buildings are supposed to be of engineered construction in a sense that they might have been analyzed and designed to meet the provision of relevant codes of practice and building bye-laws. IS 1893: 2002 “Criteria for Earthquake Resistant Design of Structures” gives response spectrum for different types of soil such as hard, medium and soft? An attempt has been made in this paper to study the effect of Soil-structure interaction on multistoried buildings with various foundation systems. Also studied the response of buildings subjected to seismic forces with Rigid and Flexible foundations. Multi storied buildings with fixed and flexible support subjected to seismic forces were analyzed under different soil conditions like hard, medium and soft. The buildings were analyzed by Response spectrum method using software STAAD Pro. The response of building frames such as Lateral deflection, Storey drift, Base shear, Axial force and Column moment values for all building frames are brought out in this paper.