Free radicals have been implicated to play pivotal role in the genesis of various oral cancers. They are generated deliberately by animal cells in certain special circumstances because these are useful entities if constrained and targated. Some enzymes require a free radical at their active site in the process of catalysis, for example, ribonucleotide reductase The free radicals cause oxidative destruction of polyunsaturated fatty acid (PUFAs) known as lipid peroxidation. It is particularly damaging because it proceeds as a self-perpetuating chain reaction; which may result in more free radical generation. Total plasma protein from an extraordinary complex mixture in serum with varities of functions. Many plasma proteins including albumin, fibrinogen and most globulins are formed in liver. Some of the proteins are produced by the reticuloendothelial system, the lymph nodes and plasma cells. All proteins fulfil some physiological and biological functions. Albumin is major plasma protein. Major functions of albumin include regulation of distribution of extracellular fluid; the amino acids in albumin form part of the body’s amino acid pool; albumin acts as a transport agent for a wide variety of substances such as hormones, lipids, vitamins, calcium and trace metals (although some substances are transported by other proteins eg. T3 cortisol and iron). It is synthesized in liver from amino acids which are absorbed in ileum. Albumin contributes to the plasma colloid osmotic pressure which tends to force water into the tissues. Uric acid by its ability to bind iron and copper can acts as an antioxidant and can inhibit lipid peroxidation and scavenge radicals