The main objective of the study was the impact of meaningful learning on stress of class XIth CBSE male and female students for achieving the objective. The investigator selected 500 CBSE Class XIth male and female students randomly. All students of the sample were divided into experimental group and control group on the basis of their intelligent. First the investigator administrator pre-test on students of both the groups after that investigator applied 30days treatment to both the group i.e. experimental group was taught by Advance Organizer Model (Meaningful Learning) Control Group taught by traditional method after treatment the post-test of stress administered by the investigator on both the group and gain scores were obtained (post-test – pre-test = gain score) and analyzed by two way analysis of variance. The result revealed that there was a significant difference for groups at 0.01 significance level and group * gender wise significant at 0.05 significance level was find.