International Research journal of Management Science and Technology
ISSN 2250 - 1959 (online) ISSN 2348 - 9367 (Print) New DOI : 10.32804/IRJMST
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A CASE STUDY OF METHOD OF PREPARATION AND EVALUATION OF FLOATING MICROSPHERES
2 Author(s): GURVEEN KAUR KAUSHAL, DR. ASHUTOSH PANDEY
Vol - 9, Issue- 9 , Page(s) : 142 - 153 (2018 ) DOI : https://doi.org/10.32804/IRJMST
The floating or hydro dynamically controlled drug-delivery systems are useful to increase the retention time of the drug-delivery systems for more than 12 h. Unfortunately floating devices administered in a single unit form (such as hydrodynemially balanced system)are unreliable in prolonging the GRT owing to their ‘all-or–nothing” emptying process and thus they may causes high variability in bioavailability and local irritation due to large amount of drug delivered at a particular site of the GIT. Glipizide is a second-generation sulfonylurea having short biological half-life (3.4 ± 0.7 hours).